United States Vice President Joe Biden announced Saturday that his son, Beau, has died of brain cancer, according to The Associated Press (AP).

Beau Biden was 46.

“It is with broken hearts that Hallie, Hunter, Ashley, Jill and I announce the passing of our husband, brother and son, Beau, after he battled brain cancer with the same integrity, courage and strength he demonstrated every day of his life,” the vice president said in a statement late Saturday.

“The entire Biden family is saddened beyond words. We know that Beau’s spirit will live on in all of us, especially through his brave wife, Hallie, and two remarkable children,” added Biden.

President Barack Obama said he and first lady Michelle were grieving alongside the Biden family.

“Michelle and I humbly pray for the good Lord to watch over Beau Biden, and to protect and comfort his family here on Earth,” Obama said.

Beau Biden was a lawyer, member of the Delaware National Guard and former Delaware attorney general.

He was hospitalized earlier this month at Walter Reed National Military Medical Center. The vice president’s office had declined at the time to specify what he was being treated for.

Biden announced last year that he would not seek a third term as attorney general and would instead run for governor in 2016, noted AP.